Philanthropy-to-lab personnel bridge

Holden Karnofsky

Former Open Philanthropy CEO and Anthropic risk-report coauthor; married to Daniela Amodei.

Former donor-side role, later lab publication

Open Philanthropy says Karnofsky stepped down as CEO in 2023 to focus on AI safety. Anthropic names him on a 2025 risk report. Karnofsky says Daniela Amodei is his wife. None of these records shows him financing or directing METR.

What the records show

Holden KarnofskyCoefficient Giving

Former CEO of Open Philanthropy

2026-09-16

The organization now named Coefficient Giving identifies Karnofsky as its former CEO, who stepped down in 2023.

From the investigation

The family connection

Dario and Daniela Amodei are siblings and Anthropic co-founders. Holden Karnofsky calls Daniela his wife; that makes him Dario's brother-in-law. Karnofsky was Open Philanthropy's CEO before stepping down in 2023 and later appears on an Anthropic risk-report byline . These are public family and career facts, not proof of METR control or an undisclosed transfer. TIME · Holden interview, p. 28 · Open Philanthropy leadership account .

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EA and TESCREAL

Open Philanthropy's own account places Karnofsky in an effective-altruist institution. Gebru and Torres's TESCREAL paper groups transhumanism, Extropianism, singularitarianism, cosmism, Rationalism, effective altruism and longtermism into a critical historical argument. It is not a membership list. A 2024 TIME profile reported Anthropic saying neither Amodei sibling personally identified as EA, while acknowledging sympathy for some ideas. Documented relationships and policy proposals can be examined without converting an ideological label into proof of a coordinated bloc.

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Further reading

Paid warnings, family links and who can publish a review

Read the original sources 3

What the connections say

3 relationships